The initial configuration should be enough for most environment, you can modify it on the fly later when you browse sites but since almost all scripts are blocked, websites' appearances will be affected as well unless we put our favorite websites on the whitelist. That being said, as good as it is, this Addon makes it hard for common people that just want to surf internet casually. Not all people have patience to do so (manually configuring the way NoScript acts). ^^
Overall, this is a good addon. I recommend it to be installed on your Firefox.